Induction Chemotherapy for Head and Neck SCC

ICT today

  • larynx preservation
    • CCRT not clearly better than ICT in pts who qualify for total laryngectomy but not partial - SALTORL trial is comparing ICT and CCRT head-to-head
  • treatment intensification
    • TPF+CCRT in the fittest patients?
  • converting borderline resectable to resectable
    • ~30% conversion rate
  • selecting HPV+ OPSCC pt for RT dose reduction
    • significant improvement in morbidity
  • oligometastatic disease
    • shrink/eliminate distant sites, spot weld prn, then CCRT/surgery?
  • neurologic and airway compromise
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