Primary Mediastinal B-Cell Lymphoma

Admission continued

• FDG-PET CT: 9.4x6.3cm mediastinal mass, LAD, diffuse axial skeleton uptake (hyperplasia vs infiltration)
• BMBx: NED
• Mediastinal bx: results came back a few days later, mostly fibrosis, crush artifact, necrosis
  • mature B-cell markers: CD20+, CD45+, PAX5+.
  • PMBCL: CD23 patchy ( -ve in DLBCL, cHL, MGZL), CD30 patchy (30% DLBCL, but weak+ in most PMBCL), CD10- (nonGC), equivocal [BCL2/6, c-MYC, MUM1], EBER-
• SVC syndrome: much back and forth re SVC stent, RT.
  • Ultimately pursued neither, sx slowly improved.