Cold Agglutinin Disease
A jaunt through history
1997
Rituximab comes to market.
1998
Lee and Kueck try rituximab (375 x4) in a pt w CAD, and it works.
2001
Berentsen et al report on a small prospective ritux study: 1 CR, 3 PR, 2 no response.
2006, 2013
Berentsen et al retrospective study: ritux-based regimens RR 67-83%.