Induction Chemotherapy for HNSCC

ICT through the ages

  • 1980s
  • 5x RCT w MTX - 4/5 -ve, 1/5 +ve only for stage II oral cavity disease (and used intra-arterial MTX)
  • many other RCTs, no benefit (outside of limited stage oral cavity disease)
  • 1990s
  • Concurrent Cisplatin-based chemoRadioTherapy (CCRT)
  • Lacas et al 2021, Radiotherapy and Oncology
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