Cold Agglutinin Disease
1964
Olesen publishes the first paper with a successful drug treatment for CAD, choosing chlorambucil based on the then-recent success of this drug in Waldenstrom macroglobulinemia. Follow-up in 1970 with 4 pts has similar results.
(One pt got cyclophosphamide for 4mo, switched to chlorambucil later on d/t drAE).
