Cold Agglutinin Disease

2024

72F, p/w hgb 3.8. A little tired.

  • Some discoloration of fingers, she says it's worse (and painful) when it's cold.
  • No notable icterus.
  • Elevated indirect bili.
  • LDH elevated. Hapto undetectable.
  • Retic elevated.
  • +RBC clumping on smear. Other cells normal in morphology and number.
  • DAT: IgG+ (weak), C3+
  • Cold agglutinin titre: way >64
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