skip to content Cold Agglutinin Disease
Differential diagnosis
- no B symptoms (may be difficult to separate from infx)
- no extramedullary disease (may push you toward MZL)
- CD5- (>50% CAD -ve for CD5), CD10- B cells: MZL vs IgM LPL (Waldenstrom)
- MYD88 L265P -ve (usu + in LPL)
- certain clusters of genomic and cytogenetic changes, e.g. KMT2D variant (69%) complete or partial gain of
chromosome 3 (93%)
- WHO 2022: CAD is now a distinct lymphoid neoplasm (CAD-associated LPD) (hopefully, more diagnostic consensus
will follow)
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