Cold Agglutinin Disease
1903
Karl Landsteiner publishes "About Relationships Between the Blood Serum and the Body Cells" (Über Beziehungen zwischen dem Blutserum und den Körperzellen), which contains a description of blood agglutination at cold temperatures (thermal amplitude 0-5C).
He's the guy who discovered blood types, under the term "iso-agglutination," and won the Nobel Prize in Medicine for this in 1930.
