Management of B-ALL in older adults

Case presentation continued

Exam notable for jaundice (1wk per wife), no edema, JVP wnl

BMBx

• >90% blasts
• positive [CD34, HLA-DR, CD38, TdT, moderate CD58, moderate cytoplasmic CD22, and moderate cytoplasmic CD79a]
• heterogeneous [CD19, CD38, dim CD10, CD20, cytoplasmic CD19]
• negative [CD33, CD11b, CD15, CD16, CD14, CD64, CD2, CD56, cytoCD3, CD117, and myeloperoxidase.]
• negative for BCR-ABL including breakapart
• Ph-like pending
• complex karyotype (specifics not available)