Management of B-ALL in older adults

Defining the cohort

Age

Just a number, as they say.

Karnofsky Performance Status

Defined in 1948, in an early paper on nitrogen mustards. 100% is completely healthy, 0% is dead, 10% is mostly dead. (MDCalc)

ECOG Performance Status

Defined in 1982 by the Eastern Cooperative Oncology Group, a simplified version of Karnofsky. 0 is completely healthy, 5 is dead, 2.5 is the VA special. (MDCalc)

Charlson Comorbidity Index CCI

Defined in 1987, somewhat out of date (e.g. "AIDS" gets 6 points by itself), but among the more useful standardized measures of biological (rather than chronological) age. (MDCalc)