Induction Chemotherapy for Head and Neck SCC

induction chemotherapy (ICT) through the ages

1960s

  • MTX

1970s

  • MTX vs cisplatin (response rate 14-41%)
  • cisplatin+bleomycin
  • cisplatin+bleomycin+[MTX vs vinca]
    • cisplatin+bleomycin+vincristine response rate 80%, CR 29%
  • cisplatin+5-FU (PF)
    • response rate 88%, CR 19%
  • PF with 120h of 5-FU
    • response rate 93%, Cr 38%
  • PF with 120h of 5-FU and higher dose of cisplatin
    • no benefit, more tox
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