Induction Chemotherapy for Head and Neck SCC

ICT through the ages

1980s

  • 5x RCT w MTX - 4/5 -ve, 1/5 +ve only for stage II oral cavity disease (and used intra-arterial MTX)
  • many other RCTs, no benefit (outside of limited stage oral cavity disease)

1990s

  • Concurrent Cisplatin-based chemoRadioTherapy (CCRT)
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