Anaplastic Thyroid Carcinoma

Management continued - chemo +/- RT

• modest overall benefit, but can be started quickly
• typically taxane+platinum or doxorubicin+taxane/platinum
• most prefer regimens with weekly dosing given rapid doubling time
  • e.g. carbo AUC2 + paclitaxel 50-100mg/m2
  • there's no real data for this, very institution and provider specific
• involve RT early for consideration of chemo+RT