Anaplastic Thyroid Carcinoma

Key points

• ATC is universally fatal, but early targeted and multidisciplinary intervention can improve outcomes, including extending survival to years in some cases
• Call pathology, get BRAF IHC and/or PCR as fast as possible
• Even if the mgmt appears to be primarily surgical, involve H&N med onc specialist up front
• TKI+IO is an attractive option, but it can be difficult to get IO approved quickly enough to make a difference
  • TKI can typically get approved quickly
• resection can be beneficial even in the metastatic setting, neoadjuvant therapies can increase the feasibility