Lower-Risk MDS

Diagnosis

  • ≥1 cytopenias
    • hgb <10, ANC <1800, plt <100k
  • ≥10% dysplastic cells in ≥1 lineage*
  • <20% blasts
  • presence of certain cytogenetic/molecular findings
    • absence of AML-defining (cyto)genetics (e.g. t(8;21), CBFB-MYH11)

* if certain cytogenetic changes**, can dx MDS w/o dysplasia (<10% of cases)

** monosomy 5, 7, or 13; 5q, 7q, and 13q deletions; i(17p) and t(17p); 11q deletion; 9q or 12p deletion; or t(12p), idic (X)(q13)

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