Lower-Risk MDS

Management - thrombocytopenia

romiplostim1

  • plt <20k: 1250 vs 1800 plt tfx per 100 pt-years
  • plt >20k: 80 vs 225 bleeding events per 100 pt-years

eltrombopag1

  • baseline plt <30k
  • improved plt count in 50% (3% in placebo)
1 TPO possibly yield higher risk of AML transformation, particularly in MDS-EB, but longer f/u studies failed to show an association (e.g. Kantarjian 2018)
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